Histocompatibility Antigens Class II

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

Also Known As:

Class II Antigen; Class II Histocompatibility Antigens; Class II MHC Proteins; Class II Major Histocompatibility Antigens; Class II Major Histocompatibility Molecules; I-A Antigen; I-A-Antigen; IA Antigen; MHC Class II Molecules; MHC II Peptides; MHC-II Molecules; Antigen, Class II; Antigen, I-A; Antigen, IA; Antigen, Ia-Like; Antigens, Class II; Antigens, Ia; Antigens, Ia-Like; Antigens, Immune-Associated; Antigens, Immune-Response-Associated; I A Antigen; II Peptide, MHC; Ia Like Antigen; Ia Like Antigens; Immune Associated Antigens; Immune Response Associated Antigens; MHC II Molecules; Molecules, MHC-II; Peptide, MHC II; Peptides, MHC II; Antigens, Immune Response; Class II Antigens; Class II Histocompatibility Antigen; Class II Major Histocompatibility Antigen; Ia Antigens; Ia-Like Antigen; Ia-Like Antigens; Immune Response Antigens; Immune-Associated Antigens; Immune-Response-Associated Antigens; MHC Class II Molecule; MHC II Peptide

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - Histocompatibility Antigens Class II: 2170
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - Histocompatibility Antigens Class II: 2170

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Disease

Drug/Important Bio-Agent (IBA)